Plot Synopsis

Inspired by the 1995 film directed by Terry Gilliam, 12 MONKEYS follows the journey of Cole, a time traveler from the post-apocalyptic future, who appears in present day on a mission to locate and eradicate the source of a deadly plague that will eventually decimate the human race. Utilizing a dangerous and untested method of time travel, he journeys from 2043 to the present day, Cole enlists the help of Dr. Cassandra Railly, who is forced to choose between her idyllic life or joining Cole's mission to uncover the dangerous conspiracy. Helping her make that decision is political strategist Aaron Marker, who tries to protect her but is pulled into the conspiracy to end the world. Plus, Ramse, Cole's best friend in the apocalyptic future, helped him survive the destruction and proves critical to the survival of the team as Cole travels through time. In the Season 1 finale, Cole and Railly attempt a final confrontation with their closest enemies, and Jones faces a new threat to all that she's accomplished. The 13-episode second season of 12 MONKEYS premiered on Monday, April 18, 2016 at 9pm ET/PT on Syfy, with Aaron Stanford (James Cole), Amanda Schull (Dr. Cassandra Railly), Kirk Acevedo (Ramse), Emily Hampshire (Jennifer Goines), Barbara Sukowa (Katarina Jones) and Todd Stashwick (Deacon) reprising their roles. Joining forces in the present with Dr. Railly, Cole must defeat a centuries-old malevolent organization known as the Army of the 12 Monkeys. As Cole, Railly and their unlikely allies get closer to the truth, they'll learn there are deadly consequences for all of history...and time itself. Guest stars this season include: Madeleine Stowe, star of the original TWELVE MONKEYS film, as Lillian, a mental patient in the 1950s who has a major impact on Cole's mission; Michael Hogan as Dr. David Eckland, a charismatic and intelligent scientist from the future with a connection to Jones; Brendan Coyle as Dr. Benjamin Kalman, a former bioengineer racked with guilt over the deadly virus his team gave birth to; Jay Karnes as a savvy FBI agent in the 1940s named Robert Gale, who believes Cole is connected to a series of grisly murders; David Dastmalchian as Kyle Slade, a Vietnam vet whose mind is connected to time itself; David Marciano as NYPD detective John Damato, who's pulled into the 1975 case of a serial killer affiliated with the Army of the 12 Monkeys; and Xander Berkeley, who returns as the tragic military leader Jonathan Foster who ran the Government's final hope to combat the plague that destroyed the world. In the season opener, "Year of the Monkey," Cole and Ramse mend their broken friendship while on the run from the Army of the 12 Monkeys. And in the year 2043, Railly and Jones navigate an uncertain future as Deacon and the Twelve command the Temporal Facility. The series' entire 10-episode third season premieres over three consecutive nights, from Friday, May 19 to Sunday, May 21 from 8-11pm ET/PT. The first four episodes debut on Friday, with three episodes airing each night on both Saturday and Sunday. Season 3 continues the journey of James Cole, a man sent back in time to eradicate the source of a deadly plague, and his partner, brilliant virologist Dr. Cassandra Railly. While attempting to untangle an insidious conspiracy that's been spun throughout centuries, the duo embark on a desperate search across time to find the man responsible for the apocalypse -- a time traveler who calls himself the Witness. Killing the Witness will save the world, but the journey will come at tremendous personal stakes for the pair. Joining the cast as recurring guest stars in Season 3 are Hannah Waddingham, Faran Tahir and James Callis. Christopher Lloyd is set to appear in a memorable guest-starring role as a deadly cult leader with sinister motives. 12 MONKEYS returned for its fourth and final chapter on Friday, June 15, 2018 from 8-11pm ET/PT, as Syfy debuted three back-to-back episodes. In Season 4, James Cole and Dr. Cassandra Railly set out on an epic quest, traveling further back in time than they have ever been before. According to legend, their only hope lies with a weapon capable of stopping the Witness for good. But they'll soon discover that in order to win the final battle and save time itself, they will have to make the ultimate sacrifice.
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On Friday, July 6, 2018 from 9-11:05pm ET/PT, Syfy premiered the series finale of 12 MONKEYS, debuting back-to-back new episodes:

"The Beginning (Part 1)" (9-10:04pm): The final battle against the Witness as the fate of time and mankind hangs in the balance. All the pieces finally come together to mark the end of the beginning.

"The Beginning (Part 2)" (10:04-11:05pm): When all hope is lost, Cole must complete his cycle so that his younger self will one day arrive at the end with the answer.