Plot Synopsis

This one-hour drama series follows the interns, residents, and doctors at Seattle Grace Hospital as they juggle their complicated personal lives with the stress and competitiveness of life-and-death medical decisions. The series started with the trials and tribulations of five first-year surgical interns: Meredith Grey, the show's namesake (and narrator) who is the daughter of a former Seattle Grace surgeon and now the wife of Derek Shepherd, the Chief of Neurosurgery; Cristina Yang, Meredith's very career-oriented best friend, who was left at the altar by Preston Burke before she married Owen Hunt many years later; Alex Karev, a discourteous womanizer, who became involved with patient Ava and was later married to Izzie Stevens before she asked him for a divorce; Izzie Stevens, who is a recent cancer survivor, fell in love with patient Denny Duquette, accidentally killed him as she tried to get him a new heart, and was later dismissed from Seattle Grace for other issues with patient care; and George O'Malley, who, despite his passive personality, still managed to sleep with Meredith, marry Callie Torres, and cheat on Callie with Izzie and who sacrificed his own life to save a girl from being hit by a bus. Having passed their boards in Season 8, Meredith, Cristina, Alex, and Jackson Avery all planned on taking positions at different hospitals, leaving Seattle Grace behind. But that was before the plane crash at the end of Season 8 that left the fates of Meredith, Derek, Cristina, Mark and Arizona in doubt, while taking the life of Lexie Grey, Meredith's half-sister and Seattle Grace resident who was in relationships with Mark, Alex, and Jackson, a surgical resident and grandson of famous surgeon Dr. Harper Avery. Meanwhile, April Kepner's career as a doctor seemed to be over when she failed her exam and was fired. Also before the crash, Meredith and Derek were focused on being new parents to baby Zola and were debating whether to move into their dream house or start over in Boston. Cristina and Owen's marriage was still on the rocks, and Callie and Arizona were happily settling into motherhood. Bailey had decided to give love another chance with her new fiance, Ben, and Richard Webber found comfort in the arms of Jackson's mother, Catherine Avery. At the end of the ninth season, the hospital staff endured another disaster -- this time, a storm hit Grey Sloan Memorial Hospital.

Season 10 opened with a two-hour premiere event that picked up with the storm that ended the previous season. A giant mudslide in Seattle injured a group of first responders and citizens, causing the already shorthanded ER to spring into action. Meanwhile, Meredith was faced with a tough decision that will affect the life of a loved one, Richard's life was in extreme danger, and Callie was rocked by the reality of Arizona's infidelity, forcing her to make a bold decision about their relationship.

GREY'S ANATOMY returned for its eleventh season on Thursday, September 25, 2014 at 8pm ET/PT on ABC. In the season opener, "I Must Have Lost It On The Wind," a new doctor, Maggie Pierce, makes the rounds and Derek wants to move to Washington DC, as Meredith struggles to regain a sense of normalcy both at home and in the hospital after Cristina's departure. Meanwhile, Callie and Arizona come to a decision about surrogacy, Amelia overhears a big secret, Bailey realizes she will have to fight Alex for Cristina's board seat and a freak accident causes two teenagers to be caught in a very compromising position.

ABC premiered Season 12 of GREY'S ANATOMY on Thursday, September 24, 2015 at 8pm ET/PT, with Debbie Allen and Joey Lauren Adams guest starring in the "Sledgehammer" episode, which is directed by series star Kevin McKidd. Seattle Grace Hospital springs into action to save the lives of two young girls whose powerful story will force some of the doctors to revisit the effects of bullying on their own pasts. Meanwhile, Meredith must adjust to changes at home with her new roommates while Bailey continues to fight for the Chief of Surgery position and Jackson prepares for April's return to Seattle.

Season 13 of GREY'S ANATOMY premiered on Thursday, September 22, 2016 at 8pm ET/PT on ABC. In the season opener, "Undo," when one of Grey Sloan's own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.

The 14th season of GREY'S ANATOMY premiered on Thursday, September 28, 2017 from 8-10pm ET/PT, as ABC debuted back-to-back new episodes: "Break Down the House" (8pm) -- Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire, and the doctors are introduced to a few new faces that spice things up around the hospital; "Get Off on the Pain" (9pm) -- Meredith struggles to come up with a new plan for Owen's sister. Jo makes a surprising choice regarding Alex, and Andrew's sister's controversial research leads to a shocking discovery.

Season 15 of GREY'S ANATOMY premiered on Thursday, September 27, 2018 from 8-10pm ET/PT on ABC. In the two-hour season opener: "With a Wonder and a Wild Desire" (8pm): The doctors at Grey Sloan Memorial vie for a new position. Meredith is seemingly distracted and struggles to stay focused, and Maggie finds herself the keeper of a big secret while Amelia and Owen try to figure out their relationship. Meanwhile, Jo and Alex's honeymoon doesn't go exactly as planned. Guest starring: Debbie Allen as Catherine Avery, Stefania Spampinato as Carina DeLuca, Jake Borelli as Levi Schmitt, Alex Blue Davis as Casey Parker and Rushi Kota as Vik Roy. "Broken Together" (9pm): Then, in the second hour, new doctors continue to shake up the hospital in typical Grey Sloan manner. Meredith bonds with a patient while Jackson struggles with the meaning behind recent experiences; and after making a life-changing decision, Jo forms an unexpected alliance. Guest starring is Chris Carmack as Link, Jake Borelli as Levi Schmitt, Alex Blue Davis as Casey Parker, Sophia Ali Taylor as Dahlia Qadri and Jaicy Elliot as Taryn Helm.

GREY'S ANATOMY returned for its 16th season on GREY'S ANATOMY on Thursday, September 26, 2019 at 8pm ET/PT on ABC. In the season opener, "Nothing Left to Cling To," written by Krista Vernoff and directed by Debbie Allen, Meredith, Richard and Alex must deal with the consequences after Bailey fires them from Grey Sloan for insurance fraud. After disappearing in the fog, Jackson helps a man in a dangerous situation, and his relationship with Maggie comes to a new crossroad. Meanwhile, Tom gets new responsibilities at the hospital that throw the doctors for a loop. On Thursday, January 23, 2020 at 9pm ET/PT, ABC debuted "Help Me Through the Night," the winter premiere of GREY'S ANATOMY and crossover episode with STATION 19. Following the car crash at Joe's Bar and subsequent rescue efforts led by the Station 19 firefighters, Grey Sloan doctors work through the night to save the lives of their colleagues. Meanwhile, Amelia worries about sharing her pregnancy revelation with Link. Owen and Teddy take a big step, and Bailey deals with grief over her recent loss.

Season 17 of GREY'S ANATOMY premiered on Thursday, November 12, 2020 from 9-11pm ET/PT on ABC with a two-hour season opener: "All Tomorrow's Parties" (9pm): In the midst of the early days of the COVID-19 pandemic, Grey Sloan Memorial and its surgeons' lives have been turned upside down. The season 17 premiere picks up one month into the pandemic, and it's all-hands-on-deck as Meredith, Bailey and the rest of the Grey Sloan doctors find themselves on the frontlines of a new era. Meanwhile, an unintentionally started fire has first responders from Station 19 bringing patients into the hospital for treatment. "The Center Won't Hold" (10pm): Bailey finds herself in the middle of an argument with patients' families as they await news about their children who were injured in a fire. Winston surprises Maggie, and Amelia and Link try to have some fun as new parents. Teddy learns her colleagues know more than she may like about her relationship woes with Owen, and Richard and Koracick go at it. After a three-month break, GREY'S ANATOMY returned for its mid-season premiere on Thursday, March 11, 2021 at 9:20pm ET/9pm PT on ABC with a crossover episode with STATION 19.

On Thursday, September 30, 2021 at 9pm ET/PT, ABC premiered the eighteenth season of GREY'S ANATOMY. This season, Kate Walsh, Kate Burton, and Abigail Spencer all return to reprise the roles of their beloved characters. In the season opener, "Here Comes the Sun," the city of Seattle revels at the Phoenix Fair celebrating the city's rebirth post-COVID, and the Grey Sloan doctors treat a patient who encounters illegal fireworks. Meanwhile, Bailey has her sights set on hiring new doctors, but she's having trouble finding viable options. Owen and Teddy attempt to take the next step in their engagement, and Meredith has a surprising opportunity when she meets a dynamic doctor from her mother's past. After a two-month break, GREY'S ANATOMY returned with new episodes on Thursday, February 24, 2022 at 9pm ET/PT on ABC. In the mid-season premiere, "No Time to Die," the Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own, while Meredith works to save Dr. Hamilton's life. After Levi is severely impacted from his latest loss, Bailey is forced to once again rethink the Webber Method. Later, Link confronts Amelia after witnessing her move on with someone new. This episode was written by Krista Vernoff and directed by Linda Klein.

Season 19 of GREY'S ANATOMY premiered on Thursday, October 6, 2022 at 9pm ET/PT on ABC. After a long six months, Grey Sloan Memorial has reinstated its residency program. A group of talented and striving young interns has been recruited as the attending surgeons work to rebuild the program to its former glory. Meredith, still functioning as the interim chief, sees Nick for the first time since she rejected his offer to move to Minnesota. Meanwhile, Bailey tells Richard she is not ready to return to work; Levi works up the courage to break disappointing news to Jo, and things turn awkward when Link realizes he has met one of the interns already. With Amelia and Maggie's help, the new doctors are thrown into their first day on the job dealing with injuries from a recent tornado. The season opener, "Everything Has Changed," was directed by Debbie Allen and written by Krista Vernoff. After a 15-week break, GREY'S ANATOMY returned with new episodes on Thursday, February 23, 2023 at 9pm ET/PT on ABC. In the winter premiere, "I'll Follow the Sun," on Meredith's last day at Grey Sloan, the doctors plan a goodbye surprise and Nick confronts her about the future of their relationship. The interns compete to scrub in on a groundbreaking procedure, and Richard asks Teddy an important question.

The 20th season of GREY'S ANATOMY debuted on Thursday, March 14, 2024 at 9pm ET/PT on ABC. In the season opener, "We've Only Just Begun," Meredith rethinks her plans after going rogue in last season's finale. The interns are on thin ice following a patient's death, but Simone and Lucas are immediately tested in an emergency. Richard confides in Bailey, and Teddy's fate is revealed.

GREY'S ANATOMY returned for its 21st season on Thursday, September 26, 2024 at 10pm ET/PT on ABC. In the season opener, "If Walls Could Talk," after firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.
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On Thursday, November 21, 2024 at 10pm ET/PT, ABC premiered "Drop It Like It's Hot," the fall finale of GREY'S ANATOMY. In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.

GREY'S ANATOMY returns with new episodes in March 2025.