Plot Synopsis

Executive produced and hosted by Drew Barrymore, THE DREW BARRYMORE SHOW is a one-hour, daytime, syndicated talk show, featuring celebrity interviews, self-help segments, lifestyle tips, games & giveaways, and comedy sketches. In the inaugural episode of THE DREW BARRYMORE SHOW, Drew introduces her new segment "Drew's News," reunites with longtime friend and co-star Adam Sandler, reunites with CHARLIE'S ANGELS co-stars Cameron Diaz and Lucy Liu, learns how to cook Chef Haile Thomas' Islander Lively Bowl, and reveals a surprise backyard makeover for essential workers -- the Copening family -- in "Designed by Drew." Plus, Jane Lynch shares her most starstruck moment, and Drew debuts "The Goodbye!" Later in during premiere week, Drew interviews: Reese Witherspoon, authors Derrick Barnes & Gordon James (Tuesday); Jane Fonda and joins Gabrielle Union (Wednesday); Tyra Banks and Charlize Theron (Thursday); and Billy Porter (Friday). Later episodes in premiere week also feature segments like: Billy Eichner playing "Would Drew Barrymore Like That?"!; a quarantine fashion show with Christian Siriano; "Stans for Stains," as Jimmy Fallon shares the story of the first time he met Paul McCartney; "Share the Mic Now" founder Luvvie Ajayi Jones; kid correspondent Jonah Larson; "Word of the Week"; and picks for weekend fun in "The Weekender." THE DREW BARRYMORE SHOW launched with a virtual audience.

Beginning with the 2022-23 season (Season 3), the show was reformatted into two half-hour programs, which could be aired back-to-back or separately -- often in conjunction with local newscasts.
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Season 5 of THE DREW BARRYMORE SHOW debuted on Monday, September 9, 2024 in national syndication (check local listings for time and channel), with Drew Barrymore returning on host. For the season opener, Drew welcomed the hosts of CBS MORNINGS: Gayle King, Nate Burleson and Vlad Duthiers. Then, the day's second episode featured Dax Shepard was the celebrity guest.