Once and Again
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| Award (↓) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| futoncritic's Best Eps | 2001 | 20 Best Eps of 2000 (#7) | Winner | |
| Entertainment Weekly's Best/Worst List | 2001 | The Ten Best (#8) | Winner | |
| Entertainment Weekly's Best/Worst List | 2000 | The Ten Best (#9) | Winner | |
| Entertainment Weekly's Best/Worst List | 1999 | The Ten Best (#4) | Winner | |
| Emmy Award | 2002 | Outstanding Casting for a Drama Series | Nominee | Amy Lippens |
| Emmy Award | 2001 | Outstanding Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| Emmy Award | 2001 | Outstanding Casting for a Drama Series | Nominee | Amy Lippens, Lizzie Scheck |
| Emmy Award | 2001 | Outstanding Lead Actress in a Drama Series | Nominee | Sela Ward |
| Emmy Award | 2000 | Outstanding Actress in a Drama Series | Winner | Sela Ward |
| Electronic Media's Critics Poll | 2001.07 | Best Television Series (#9) | Winner | |
| Electronic Media's Critics Poll | 2001.01 | Best Television Series (#8) | Winner | |
| Electronic Media's Critics Poll | 2000.07 | Best Television Series (#7) | Winner | |
| Electronic Media's Critics Poll | 2000.01 | Best Television Series (#10) | Winner | |
| Cadet Award | 2002 | Outstanding Guest Actor in a Drama Series | Winner | Patrick Dempsey |
| Cadet Award | 2002 | Outstanding Guest Actress in a Drama Series | Nominee | Ally Sheedy |
| Cadet Award | 2002 | Outstanding Writing in a Drama Series | Nominee | Richard Kramer |
| Cadet Award | 2002 | Outstanding Directing in a Drama Series | Nominee | Edward Zwick, Marshall Herskovitz |
| Cadet Award | 2002 | Outstanding Drama Series | Nominee | |
| Cadet Award | 2002 | Outstanding Lead Actor in a Drama Series | Nominee | Billy Campbell |
| Cadet Award | 2002 | Outstanding Lead Actress in a Drama Series | Nominee | Sela Ward |
| Cadet Award | 2002 | Outstanding Supporting Actress in a Drama Series | Winner | Susanna Thompson |
| Cadet Award | 2001 | Outstanding Drama Series | Nominee | |
| Cadet Award | 2001 | Outstanding Lead Actor in a Drama Series | Winner | Billy Campbell |
| Cadet Award | 2001 | Outstanding Lead Actress in a Drama Series | Nominee | Sela Ward |
| Cadet Award | 2001 | Outstanding Supporting Actress in a Drama Series | Nominee | Susanna Thompson |
| Cadet Award | 2001 | Outstanding Supporting Actress in a Drama Series | Nominee | Evan Rachel Wood |
| Cadet Award | 2001 | Outstanding Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| Cadet Award | 2001 | Outstanding Guest Actress in a Drama Series | Nominee | Barbara Barrie |
| Cadet Award | 2001 | Outstanding Writing in a Drama Series | Nominee | Winnie Holzman |
| Cadet Award | 2001 | Outstanding Directing in a Drama Series | Nominee | Dan Lerner |
| Cadet Award | 2001 | Outstanding Music Composition (Dramatic Underscore) | Nominee | |
| Cadet Award | 2000 | Outstanding Drama Series | Nominee | |
| Cadet Award | 2000 | Outstanding Debut Series | Winner | |
| Cadet Award | 2000 | Outstanding Lead Actor in a Drama Series | Nominee | Billy Campbell |
| Cadet Award | 2000 | Outstanding Lead Actress in a Drama Series | Winner | Sela Ward |
| Cadet Award | 2000 | Outstanding Supporting Actress in a Drama Series | Nominee | Susanna Thompson |
| Cadet Award | 2000 | Outstanding Guest Actress in a Drama Series | Nominee | Bonnie Bartlett |
| Cadet Award | 2000 | Outstanding Writing in a Drama Series | Nominee | Ed Zwick, Marshall Herskovitz |
| Cadet Award | 2000 | Outstanding Directing in a Drama Series | Nominee | Dan Lerner |
| Cadet Award | 2000 | Outstanding Casting | Nominee | |
| Cadet Award | 2000 | Outstanding Music Composition | Nominee | |
| Artios Award | 2002 | Best Casting for an Episodic Drama Series | Nominee | Amy Lippens |
| Amy Award | 2002 | Call the Voodoo Doctor, I Want to Resurrect __________ | Nominee | entire cast |
| Amy Award | 2002 | Best Storyline of the Season | Nominee | Karen's depression |
