Once and Again
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| Award (↓) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Petcabus Award | 2001 | Best Recurring or Guest Actor or Actress in a Comedy or Drama Series | Nominee | Patrick Dempsey |
| Petcabus Award | 2001 | Best Drama Series | Nominee | |
| Petcabus Award | 2001 | Best Actress in a Drama Series | Nominee | Sela Ward |
| Petcabus Award | 2001 | Best Supporting Actress in a Drama Series | Winner | Evan Rachel Wood |
| Petcabus Award | 2000 | Best Drama Series | Winner | |
| Petcabus Award | 2000 | Best Actress in a Drama Series | Nominee | Sela Ward |
| Petcabus Award | 2000 | Best Ensemble Cast in a Drama Series | Nominee | |
| People's Choice Award | 2000 | Favorite Male Performer in a New Television Series | Winner | Billy Campbell |
| People's Choice Award | 2000 | Favorite Female Performer in a New Television Series | Nominee | Sela Ward |
| People Magazine's Best/Worst List | 1999 | Best of Tube | Winner | |
| Online Television Academy Award | 2002 | Best Guest Actor in a Drama Series | Winner | Patrick Dempsey |
| Online Television Academy Award | 2002 | Best Writing in a Drama Series | Nominee | |
| Online Television Academy Award | 2002 | Best Episode in a Drama Series | Nominee | |
| Online Television Academy Award | 2002 | Best Drama Series | Nominee | |
| Online Television Academy Award | 2002 | Best Lead Actress in a Drama Series | Nominee | Sela Ward |
| Online Television Academy Award | 2002 | Best Supporting Actress in a Drama Series | Winner | Susanna Thompson |
| Online Television Academy Award | 2002 | Best Supporting Actress in a Drama Series | Nominee | Evan Rachel Wood |
| Online Television Academy Award | 2002 | Best Ensemble Cast in a Drama Series | Nominee | |
| Online Television Academy Award | 2001 | Best Lead Actor in a Drama Series | Nominee | Billy Campbell |
| Online Television Academy Award | 2001 | Best Lead Actress in a Drama Series | Winner | Sela Ward |
| Online Television Academy Award | 2001 | Best Supporting Actress in a Drama Series | Nominee | Evan Rachel Wood |
| Online Television Academy Award | 2001 | Best Ensemble Cast in a Drama Series | Nominee | |
| Online Television Academy Award | 2001 | Best Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| Online Television Academy Award | 2001 | Best Guest Actress in a Drama Series | Nominee | Barbara Barrie |
| Online Television Academy Award | 2001 | Best Direction in a Drama Series | Nominee | |
| Online Television Academy Award | 2001 | Best Writing in a Drama Series | Nominee | |
| Online Television Academy Award | 2001 | Best Episode in a Drama Series | Nominee | |
| Online Television Academy Award | 2001 | Best Drama Series | Nominee | |
| Online Television Academy Award | 2000 | Best Drama Series | Nominee | |
| Online Television Academy Award | 2000 | Best New Drama Series | Nominee | |
| Online Television Academy Award | 2000 | Best Lead Actress in a Drama Series | Nominee | Sela Ward |
| Online Television Academy Award | 2000 | Best Ensemble Cast in a Drama Series | Nominee | |
| Online Television Academy Award | 2000 | Best Actor in a New Drama Series | Nominee | Billy Campbell |
| Online Television Academy Award | 2000 | Best Actress in a New Drama Series | Winner | Sela Ward |
| Online Television Academy Award | 2000 | Best Writing in a Drama Series | Nominee | |
| Humanitas Prize | 2001 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Winner | Marshall Herksovitz, Edward Zwick |
| Golden Satellite Award | 2002 | Best Actress in a Television Drama Series | Nominee | Sela Ward |
| Golden Satellite Award | 2001 | Best Television Drama Series | Nominee | |
| Golden Satellite Award | 2001 | Best Actress in a Television Drama Series | Nominee | Sela Ward |
| Golden Globe Award | 2002 | Outstanding Actress in a Television Drama Series | Nominee | Sela Ward |
| Golden Globe Award | 2001 | Outstanding Actress in a Television Drama Series | Winner | Sela Ward |
| Golden Globe Award | 2000 | Outstanding Television Drama Series | Nominee | |
| Golden Globe Award | 2000 | Outstanding Actor in a Television Drama Series | Nominee | Billy Campbell |
| Golden Globe Award | 2000 | Outstanding Actress in a Television Drama Series | Nominee | Sela Ward |
| GLAAD Media Award | 2003 | Outstanding Television Drama Series | Nominee | |
| futoncritic's Best Eps | 2003 | 50 Best Eps of 2002 (#6) | Winner | |
| futoncritic's Best Eps | 2003 | 50 Best Eps of 2002 (#16) | Winner | |
| futoncritic's Best Eps | 2002 | 50 Best Eps of 2001 (#42) | Winner | |
| futoncritic's Best Eps | 2002 | 50 Best Eps of 2001 (#12) | Winner | |
| futoncritic's Best Eps | 2001 | 20 Best Eps of 2000 (#16) | Winner |
