Malcolm in the Middle
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| Award (↓) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Cadet Award | 2000 | Outstanding Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| Cadet Award | 2000 | Outstanding Guest Actress in a Comedy Series | Winner | Beatrice Arthur |
| Cadet Award | 2000 | Outstanding Writing in a Comedy Series | Nominee | Linwood Boomer |
| Cadet Award | 2000 | Outstanding Directing in a Comedy Series | Nominee | Todd Holland |
| Cadet Award | 2000 | Outstanding Directing in a Comedy Series | Nominee | Ken Kwapis |
| Cadet Award | 2000 | Outstanding Editing | Nominee | |
| Cadet Award | 2000 | Outstanding Main Title Design | Nominee | |
| Cadet Award | 2000 | Outstanding Production Design | Nominee | |
| British Comedy Award | 2003 | Best International Comedy TV Show | Winner | |
| BMI TV Music Award | 2000 | Winner | John Linnel; John Flansburgh | |
| Artios Award | 2002 | Best Casting for an Episodic Comedy Series | Nominee | Barbara Miller |
| Artios Award | 2000 | Best Casting for an Episodic Comedy Series | Nominee | Nikki Valko, Ken Miller |
| Artios Award | 2000 | Best Casting for a Comedy Pilot | Winner | Mary V. Buck, Susan Edelman |
| AOL Television Award | 2001 | Best Theme Song | Nominee | |
| AOL Television All Time Lists | 2008 | TV's 50 Best Comedies of All Time (#42) | Winner | |
| American Film Institute Award | 2001 | Outstanding Comedy Series | Nominee | |
| American Film Institute Award | 2001 | Outstanding Actress in a Television Series | Nominee | Jane Kaczmarek |
| American Comedy Awards | 2001 | Funniest Lead Female Performer in a Television Series | Winner | Jane Kaczmarek |
| American Comedy Awards | 2001 | Funniest Guest Female Performer in a Television Series | Winner | Beatrice Arthur |
| American Choreography Award | 2004 | Outstanding Choreography in Episodic Television | Winner | Fred Tallaksen |
| about.com Primetime TV Awards | 2003 | Best Actress in a Comedy Series | Nominee | Jane Kaczmarek |
