Once and Again
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| Award (↑) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| RATTY Award | 2002 | Best Writing in a Drama Series | Nominee | Richard Kramer |
| RATTY Award | 2002 | Best Directing in a Drama Series | Nominee | Marshall Herskovitz, Edward Zwick |
| RATTY Award | 2002 | Best Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| RATTY Award | 2001 | Best Drama Series | Nominee | |
| RATTY Award | 2001 | Best Lead Actress in a Drama Series | Nominee | Sela Ward |
| RATTY Award | 2001 | Best Supporting Actress in a Drama Series | Nominee | Susanna Thompson |
| RATTY Award | 2001 | Best Supporting Actress in a Drama Series | Nominee | Evan Rachel Wood |
| RATTY Award | 2001 | Best Writing in a Drama Series | Winner | Marshall Herskovitz, Ed Swick |
| RATTY Award | 2001 | Best Directing in a Drama Series | Nominee | Dan Lerner |
| RATTY Award | 2001 | Best Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| RATTY Award | 2000 | Best Lead Actress in a Drama Series | Winner | Sela Ward |
| RATTY Award | 2000 | Best Guest Actress in a Drama Series | Nominee | Bonnie Bartlett |
| RATTY Award | 2000 | Best Writing in a Drama Series | Nominee | Liberty Godshall |
| RATTY Award | 2000 | Best New Series | Nominee | |
| RATTY Award | 2000 | Series with the Most Potential | Nominee | |
| Salon's Best/Worst | 1999 | Ten Best Shows (#5) | Winner | |
| Screen Actors Guild Award | 2001 | Outstanding Performance by an Actress in a Television Drama Series | Nominee | Sela Ward |
| SHINE Award | 2000 | Drama Episode | Nominee | |
| Teen Choice Award | 2002 | Choice TV Actor in a Drama Series | Nominee | Shane West |
| Teen Choice Award | 2000 | Choice TV Drama Series | Nominee | |
| Television Critics Association Award | 2000 | Outstanding Drama Series | Nominee | |
| Television Critics Association Award | 2000 | Outstanding New Program of the Year | Nominee | |
| Television Critics Association Award | 2000 | Outstanding Individual Achievement in a Drama Series | Nominee | Sela Ward |
| TV Guide Award (televised) | 2001 | Favorite Actress in a Drama Series | Nominee | Sela Ward |
| TV Guide Award (televised) | 2000 | Favorite Actor in a New Series | Nominee | Billy Campbell |
| TV Guide Award (televised) | 2000 | Favorite Actress in a New Series | Nominee | Sela Ward |
| TV Guide Award (televised) | 2000 | Favorite New Series | Nominee | |
| TV Guide's All Time Greatest/Worst Lists | 2004 | 50 Greatest TV Dads of All Time (#36) | Winner | Billy Campbell |
| USA Today's Best & Worst of TV | 2001 | Best of TV (#6) | Winner | |
| USA Today's Best & Worst of TV | 2000 | Best of TV (#2) | Winner | |
| Viewers for Quality Television Award | 2000 | Best Quality Drama Series | Nominee | |
| Viewers for Quality Television Award | 2000 | Best Actress in a Quality Drama Series | Winner | Sela Ward |
| Viewers Voice Award | 2001 | Favorite Actor in a Drama Series | Nominee | Billy Campbell |
| Wand Award | 2002 | Biggest Tearjerker | Nominee | season finale |
| Wand Award | 2002 | Show You'll Miss the Most | Nominee | |
| Wand Award | 2002 | Drama Queen | Nominee | Sela Ward |
| Wand Award | 2002 | Star You'll Miss the Most | Nominee | Sela Ward |
| Wand Award | 2002 | Best Chemistry Best Chemistry Best Chemistry Best Chemistry | Nominee | Sela Ward & Billy Campbell |
| Wand Award | 2001 | Best Chemistry | Nominee | Lily and Rick |
| Wand Award | 2001 | Best Show | Nominee | |
| Writers Guild Award | 2001 | Best Writing in an Episodic Drama Series for Television | Nominee | Richard Kramer |
| Young Artist Award | 2001 | Best Performance by a Young Ensemble in a Television Comedy or Drama Series | Winner | |
| Young Artist Award | 2000 | Best Performance by a Supporting Young Actress in a Television Drama Series | Nominee | Julia Whelan |
| Young Star Award | 2000 | Best Performance by a Young Actress in a Drama Television Series | Nominee | Evan Rachel Wood |
