Malcolm in the Middle
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| Award (↑) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Petcabus Award | 2001 | Best Comedy Series | Nominee | |
| Petcabus Award | 2001 | Best Actor in a Comedy Series | Nominee | Frankie Muniz |
| Petcabus Award | 2001 | Best Actress in a Comedy Series | Winner | Jane Kaczmarek |
| Petcabus Award | 2001 | Best Supporting Actor in a Comedy Series | Winner | Bryan Cranston |
| Petcabus Award | 2000 | Best Comedy Series | Nominee | |
| Petcabus Award | 2000 | Best Actor in a Comedy Series | Nominee | Frankie Muniz |
| Petcabus Award | 2000 | Best Actress in a Comedy Series | Nominee | Jane Kaczmarek |
| Petcabus Award | 2000 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| Petcabus Award | 2000 | Best Guest Actor or Actress in a Comedy or Drama Series | Nominee | Beatrice Arthur |
| PRISM Award | 2002 | Outstanding Television Comedy Series Episode | Winner | |
| RATTY Award | 2004 | Best Guest Actress in a Comedy Series | Nominee | Cloris Leachman |
| RATTY Award | 2003 | Best Comedy Series | Nominee | |
| RATTY Award | 2003 | Best Lead Actor in a Comedy Series | Winner | Bryan Cranston |
| RATTY Award | 2003 | Best Lead Actress in a Comedy Series | Winner | Jane Kaczmarek |
| RATTY Award | 2003 | Best Guest Actor in a Comedy Series | Winner | Christopher Lloyd |
| RATTY Award | 2003 | Best Writing in a Comedy Series | Nominee | Nahnatchka Khan, Alexandra Kaczenski |
| RATTY Award | 2003 | Best Directing in a Comedy Series | Nominee | Todd Holland |
| RATTY Award | 2003 | Best Directing in a Comedy Series | Nominee | Ken Kwapis |
| RATTY Award | 2002 | Best Comedy Series | Nominee | |
| RATTY Award | 2002 | Best Lead Actor in a Comedy Series | Winner | Frankie Muniz |
| RATTY Award | 2002 | Best Lead Actress in a Comedy Series | Winner | Jane Kaczmarek |
| RATTY Award | 2002 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| RATTY Award | 2002 | Best Writing in a Comedy Series | Nominee | Ian Busch |
| RATTY Award | 2002 | Best Directing in a Comedy Series | Nominee | Todd Holland |
| RATTY Award | 2002 | Best Guest Actress in a Comedy Series | Winner | Cloris Leachman |
| RATTY Award | 2002 | Best Guest Actress in a Comedy Series | Nominee | Susan Sarandon |
| RATTY Award | 2001 | Best Comedy Series | Winner | |
| RATTY Award | 2001 | Best Lead Actor in a Comedy Series | Nominee | Frankie Muniz |
| RATTY Award | 2001 | Best Lead Actress in a Comedy Series | Winner | Jane Kaczmarek |
| RATTY Award | 2001 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| RATTY Award | 2001 | Best Writing in a Comedy Series | Nominee | Ian Busch |
| RATTY Award | 2001 | Best Writing in a Comedy Series | Winner | Dan Kopelman |
| RATTY Award | 2001 | Best Directing in a Comedy Series | Winner | Todd Holland |
| RATTY Award | 2001 | Best Guest Actor in a Comedy Series | Winner | Robert Loggia |
| RATTY Award | 2001 | Best Ensemble in a Comedy Series | Winner | |
| RATTY Award | 2000 | Best Comedy Series | Winner | |
| RATTY Award | 2000 | Best Ensemble in a Comedy Series | Nominee | |
| RATTY Award | 2000 | Best Lead Actor in a Comedy Series | Winner | Frankie Muniz |
| RATTY Award | 2000 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| RATTY Award | 2000 | Best Supporting Actress in a Comedy Series | Winner | Jane Kaczmarek |
| RATTY Award | 2000 | Best Guest Actor in a Comedy Series | Nominee | Craig Lamar Traylor |
| RATTY Award | 2000 | Best Guest Actress in a Comedy Series | Winner | Beatrice Arthur |
| RATTY Award | 2000 | Best Writing in a Comedy Series | Winner | Linwood Boomer |
| RATTY Award | 2000 | Best Writing in a Comedy Series | Nominee | Michael Glouberman, Andrew Orenstein |
| RATTY Award | 2000 | Best Directing in a Comedy Series | Winner | Todd Holland |
| RATTY Award | 2000 | Best New Series | Nominee | |
| RATTY Award | 2000 | Series with the Most Potential | Winner | |
| Screen Actors Guild Award | 2003 | Outstanding Performance by an Actress in a Television Comedy Series | Nominee | Jane Kaczmarek |
| Screen Actors Guild Award | 2001 | Outstanding Performance by an Actress in a Television Comedy Series | Nominee | Jane Kaczmarek |
| Teen Choice Award | 2005 | Choice TV Actor in a Comedy Series | Nominee | Frankie Muniz |
