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| Award | Year (↓) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Humanitas Prize | 2006 | 30 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | Garrett Donovan & Neil Goldman |
| futoncritic's Best Eps | 2006 | 50 Best Eps of 2005 (#23) | Winner | |
| Cadet Award | 2006 | Outstanding Comedy Series | Nominee | |
| Artios Award | 2006 | Best Casting for an Episodic Comedy Series | Nominee | Brett Benner; Debby Romano |
| Box Office Prophet Reader Award | 2006 | Best TV Show (#6) | Winner | |
| Cadet Award | 2006 | Outstanding Directing in a Comedy Series | Nominee | Zach Braff |
| RATTY Award | 2006 | Best Comedy Series | Nominee | |
| RATTY Award | 2006 | Best Directing in a Comedy Series | Nominee | Zach Braff |
| Teen Choice Award | 2006 | Choice TV Sidekick | Nominee | Donald Faison |
| Teen Choice Award | 2006 | Choice TV Actor - Comedy | Nominee | Zach Braff |
| Golden Laurel Award | 2006 | Danny Thomas Producer of the Year for Episodic Comedy Television | Nominee | |
| RATTY Award | 2006 | Best Guest Actor in a Comedy Series | Nominee | Tom Cavanagh |
| Cadet Award | 2006 | Outstanding Lead Actor in a Comedy Series | Winner | Zach Braff |
| Emmy Award | 2006 | Outstanding Comedy Series | Nominee | |
| MediaVillage TV Fan Award | 2006 | Outstanding Actor in a Comedy Series | Winner | Zach Braff |
| RATTY Award | 2006 | Best Guest Actress in a Comedy Series | Nominee | Mandy Moore |
| Calvin Award | 2006 | Best TV Show (#5) | Winner | |
| Internet TV Award | 2006 | Favorite Primetime Comedy Series | Winner | |
| Golden Tater Award | 2006 | Best Guest Star (#3, tie) | Voted | Jason Bateman |
| RATTY Award | 2006 | Best Lead Actor in a Comedy Series | Nominee | Zach Braff |
| Tubey Award | 2006 | Best Comedy (#3) | Voted | |
| RATTY Award | 2006 | Best Lead Actress in a Comedy Series | Nominee | Sarah Chalke |
| Internet TV Award | 2006 | Favorite Actor in a Primetime Comedy Series | Winner | Zach Braff |
| Tubey Award | 2006 | Most Overlooked Show (#3) | Voted | |
| Internet TV Award | 2006 | Favorite Actress in a Primetime Comedy Series | Winner | Sarah Chalke |
| Golden Tater Award | 2006 | Favorite Funnyguy (#1) | Voted | Zach Braff |
| Golden Tater Award | 2006 | Favorite Funnyguy (#6) | Voted | Donald Faison |
| TelevisionWeek's Critics Poll | 2005.01 | Best Television (#17) | Winner | |
| Imagen Award | 2005 | Best Lead Actress in Television | Nominee | Judy Reyes |
| Cadet Award | 2005 | Outstanding Comedy Series | Nominee | |
| Online Television Academy Award | 2005 | Best Guest Actor in a Comedy Series | Nominee | Michael J. Fox |
| Online Television Academy Award | 2005 | Best Guest Actor in a Comedy Series | Winner | Brendan Fraser |
| Emmy Award | 2005 | Outstanding Multi-Camera Picture Editing for a Series | Winner | John F. Michel |
| Cadet Award | 2005 | Outstanding Directing in a Comedy Series | Nominee | Adam Bernstein |
| Golden Satellite Award | 2005 | Best Television Comedy or Musical Series | Nominee | |
| BET Comedy Award | 2005 | Outstanding Supporting Actor in a Comedy Series | Winner | Donald Faison |
| Tubey Award | 2005 | Best Comedy (#2) | Voted | |
| Online Television Academy Award | 2005 | Best Lead Actor in a Comedy Series | Nominee | Zach Braff |
| Tubey Award | 2005 | Most Overlooked Show (#3) | Voted | |
| RATTY Award | 2005 | Most Improved Series | Nominee | |
| futoncritic's Best Eps | 2005 | 50 Best Eps of 2004 (#44) | Winner | |
| TeeVee Award | 2005 | Best Half-Hour Actor | Winner | Donald Faison |
| Emmy Award | 2005 | Outstanding Casting for a Comedy Series | Nominee | Brent Benner; Debby Romano |
| Golden Laurel Award | 2005 | Danny Thomas Producer of the Year for Episodic Comedy Television | Nominee | |
| Cadet Award | 2005 | Outstanding Lead Actor in a Comedy Series | Nominee | Zach Braff |
| Golden Tater Award | 2005 | Favorite Funnyguy (#1) | Voted | Zach Braff |
| futoncritic's Best Eps | 2005 | 50 Best Eps of 2004 (#16) | Winner | |
| Emmy Award | 2005 | Outstanding Comedy Series | Nominee | |
| NAACP Image Award | 2005 | Outstanding Supporting Actor in a Comedy Series | Nominee | Donald Faison |
| Teen Choice Award | 2005 | Choice TV Actor in a Comedy Series | Nominee | Zach Braff |
