Once and Again
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| Award | Year (↓) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Golden Globe Award | 2000 | Outstanding Actor in a Television Drama Series | Nominee | Billy Campbell |
| Young Star Award | 2000 | Best Performance by a Young Actress in a Drama Television Series | Nominee | Evan Rachel Wood |
| Golden Globe Award | 2000 | Outstanding Actress in a Television Drama Series | Nominee | Sela Ward |
| Online Television Academy Award | 2000 | Best Ensemble Cast in a Drama Series | Nominee | |
| PRISM Award | 2000 | Outstanding Television Drama Series Episode | Winner | |
| RATTY Award | 2000 | Best Lead Actress in a Drama Series | Winner | Sela Ward |
| SHINE Award | 2000 | Drama Episode | Nominee | |
| Online Television Academy Award | 2000 | Best Actor in a New Drama Series | Nominee | Billy Campbell |
| Entertainment Weekly's Best/Worst List | 2000 | The Ten Best (#9) | Winner | |
| Online Television Academy Award | 2000 | Best Actress in a New Drama Series | Winner | Sela Ward |
| Cadet Award | 2000 | Outstanding Drama Series | Nominee | |
| Petcabus Award | 2000 | Best Drama Series | Winner | |
| Cadet Award | 2000 | Outstanding Debut Series | Winner | |
| Television Critics Association Award | 2000 | Outstanding Drama Series | Nominee | |
| Viewers for Quality Television Award | 2000 | Best Quality Drama Series | Nominee | |
| Cadet Award | 2000 | Outstanding Lead Actor in a Drama Series | Nominee | Billy Campbell |
| RATTY Award | 2000 | Best Guest Actress in a Drama Series | Nominee | Bonnie Bartlett |
| Young Artist Award | 2000 | Best Performance by a Supporting Young Actress in a Television Drama Series | Nominee | Julia Whelan |
| Television Critics Association Award | 2000 | Outstanding New Program of the Year | Nominee | |
| Online Television Academy Award | 2000 | Best Writing in a Drama Series | Nominee | |
| Cadet Award | 2000 | Outstanding Lead Actress in a Drama Series | Winner | Sela Ward |
| Television Critics Association Award | 2000 | Outstanding Individual Achievement in a Drama Series | Nominee | Sela Ward |
| USA Today's Best & Worst of TV | 2000 | Best of TV (#2) | Winner | |
| Petcabus Award | 2000 | Best Actress in a Drama Series | Nominee | Sela Ward |
| RATTY Award | 2000 | Best Writing in a Drama Series | Nominee | Liberty Godshall |
| Cadet Award | 2000 | Outstanding Supporting Actress in a Drama Series | Nominee | Susanna Thompson |
| People's Choice Award | 2000 | Favorite Male Performer in a New Television Series | Winner | Billy Campbell |
| Cadet Award | 2000 | Outstanding Guest Actress in a Drama Series | Nominee | Bonnie Bartlett |
| People's Choice Award | 2000 | Favorite Female Performer in a New Television Series | Nominee | Sela Ward |
| Petcabus Award | 2000 | Best Ensemble Cast in a Drama Series | Nominee | |
| Cadet Award | 2000 | Outstanding Writing in a Drama Series | Nominee | Ed Zwick, Marshall Herskovitz |
| Emmy Award | 2000 | Outstanding Actress in a Drama Series | Winner | Sela Ward |
| TV Guide Award (televised) | 2000 | Favorite Actor in a New Series | Nominee | Billy Campbell |
| Viewers for Quality Television Award | 2000 | Best Actress in a Quality Drama Series | Winner | Sela Ward |
| Cadet Award | 2000 | Outstanding Directing in a Drama Series | Nominee | Dan Lerner |
| TV Guide Award (televised) | 2000 | Favorite Actress in a New Series | Nominee | Sela Ward |
| RATTY Award | 2000 | Best New Series | Nominee | |
| RATTY Award | 2000 | Series with the Most Potential | Nominee | |
| TV Guide Award (televised) | 2000 | Favorite New Series | Nominee | |
| Cadet Award | 2000 | Outstanding Casting | Nominee | |
| Cadet Award | 2000 | Outstanding Music Composition | Nominee | |
| People Magazine's Best/Worst List | 1999 | Best of Tube | Winner | |
| Salon's Best/Worst | 1999 | Ten Best Shows (#5) | Winner | |
| Entertainment Weekly's Best/Worst List | 1999 | The Ten Best (#4) | Winner |
