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| Award | Year (↑) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| NAACP Image Award | 2006 | Outstanding Actor in a Comedy Series | Nominee | Donald Faison |
| ALMA Award | 2006 | Outstanding Actress in a Television Series | Winner | Judy Reyes |
| Tubey Award | 2006 | Best Credit Sequence (#3) | Voted | |
| Golden Tater Award | 2006 | Best Comedy (#1) | Voted | |
| Zap2it Best/Worst | 2006 | TV Gal's Best in Show (#7) | Winner | |
| Television Critics Association Award | 2006 | Outstanding Achievement in a Comedy Series | Nominee | |
| Golden Globe Award | 2006 | Outstanding Actor in a Television Comedy or Musical Series | Nominee | Zach Braff |
| Broadcasting & Cable Critics Poll | 2006 | Best Comedy (#3) | Voted | |
| Tubey Award | 2006 | Best Relationship (#2) | Voted | J.D. & Turk |
| Cadet Award | 2006 | Outstanding Ensemble in a Comedy Series | Nominee | |
| Humanitas Prize | 2006 | 30 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | Garrett Donovan & Neil Goldman |
| futoncritic's Best Eps | 2006 | 50 Best Eps of 2005 (#23) | Winner | |
| Cadet Award | 2006 | Outstanding Comedy Series | Nominee | |
| Artios Award | 2006 | Best Casting for an Episodic Comedy Series | Nominee | Brett Benner; Debby Romano |
| Box Office Prophet Reader Award | 2006 | Best TV Show (#6) | Winner | |
| Cadet Award | 2006 | Outstanding Directing in a Comedy Series | Nominee | Zach Braff |
| RATTY Award | 2006 | Best Comedy Series | Nominee | |
| RATTY Award | 2006 | Best Directing in a Comedy Series | Nominee | Zach Braff |
| Teen Choice Award | 2006 | Choice TV Sidekick | Nominee | Donald Faison |
| Teen Choice Award | 2006 | Choice TV Actor - Comedy | Nominee | Zach Braff |
| Golden Laurel Award | 2006 | Danny Thomas Producer of the Year for Episodic Comedy Television | Nominee | |
| RATTY Award | 2006 | Best Guest Actor in a Comedy Series | Nominee | Tom Cavanagh |
| Cadet Award | 2006 | Outstanding Lead Actor in a Comedy Series | Winner | Zach Braff |
| Emmy Award | 2006 | Outstanding Comedy Series | Nominee | |
| MediaVillage TV Fan Award | 2006 | Outstanding Actor in a Comedy Series | Winner | Zach Braff |
| RATTY Award | 2006 | Best Guest Actress in a Comedy Series | Nominee | Mandy Moore |
| Calvin Award | 2006 | Best TV Show (#5) | Winner | |
| Internet TV Award | 2006 | Favorite Primetime Comedy Series | Winner | |
| Golden Tater Award | 2006 | Best Guest Star (#3, tie) | Voted | Jason Bateman |
| RATTY Award | 2006 | Best Lead Actor in a Comedy Series | Nominee | Zach Braff |
| Tubey Award | 2006 | Best Comedy (#3) | Voted | |
| RATTY Award | 2006 | Best Lead Actress in a Comedy Series | Nominee | Sarah Chalke |
| Internet TV Award | 2006 | Favorite Actor in a Primetime Comedy Series | Winner | Zach Braff |
| Tubey Award | 2006 | Most Overlooked Show (#3) | Voted | |
| Internet TV Award | 2006 | Favorite Actress in a Primetime Comedy Series | Winner | Sarah Chalke |
| Golden Tater Award | 2006 | Favorite Funnyguy (#1) | Voted | Zach Braff |
| Golden Tater Award | 2006 | Favorite Funnyguy (#6) | Voted | Donald Faison |
| TelevisionWeek's Critics Poll | 2006.02 | Best Television (#13) | Winner | |
| Emmy Award | 2007 | Outstanding Directing for a Comedy Series | Nominee | Will Mackenzie |
| futoncritic's Best Eps | 2007 | 50 Best Eps of 2006 (#38) | Winner | |
| Impact Award | 2007 | Outstanding Performance in a Comedy Series | Winner | Judy Reyes |
| Tubey Award | 2007 | Best HoYay! Moment (#2) | Voted | Guy Love song |
| Imagen Award | 2007 | Best Lead Actress in Television | Nominee | Judy Reyes |
| American Latino TV Awards | 2007 | Favorite American Latino Actor | Nominee | Judy Reyes |
| ALMA Award | 2007 | Outstanding Director in a Television Series, Mini-series or TV Movie | Nominee | Linda Mendoza |
| Golden Globe Award | 2007 | Outstanding Actor in a Television Comedy or Musical Series | Nominee | Zach Braff |
| Humanitas Prize | 2007 | 30 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | Bill Callahan |
| Emmy Award | 2007 | Outstanding Original Music and Lyrics | Nominee | Debra Fordham; Robert Lopez; Jeff Marx |
| Emmy Award | 2007 | Outstanding Original Music and Lyrics | Nominee | Debra Fordham; Paul F. Perry |
| RATTY Award | 2007 | Best Comedy Series | Nominee |
